Inter- and intrasubject variability of solid and liquid gastric emptying parameters. A scintigraphic study in healthy subjects and diabetic patients.
Identifieur interne : 004985 ( Main/Exploration ); précédent : 004984; suivant : 004986Inter- and intrasubject variability of solid and liquid gastric emptying parameters. A scintigraphic study in healthy subjects and diabetic patients.
Auteurs : RBID : pubmed:8281844English descriptors
- KwdEn :
- Diabetes Mellitus, Type 1 (complications), Diabetes Mellitus, Type 1 (physiopathology), Diabetes Mellitus, Type 1 (radionuclide imaging), Female, Food, Gastric Emptying (physiology), Humans, Indium Radioisotopes (diagnostic use), Male, Middle Aged, Pentetic Acid (diagnostic use), Reproducibility of Results, Stomach (radionuclide imaging), Stomach Diseases (etiology), Stomach Diseases (radionuclide imaging), Technetium (diagnostic use).
- MESH :
- chemical , diagnostic use : Indium Radioisotopes, Pentetic Acid, Technetium.
- complications : Diabetes Mellitus, Type 1.
- etiology : Stomach Diseases.
- physiology : Gastric Emptying.
- physiopathology : Diabetes Mellitus, Type 1.
- radionuclide imaging : Diabetes Mellitus, Type 1, Stomach, Stomach Diseases.
- Female, Food, Humans, Male, Middle Aged, Reproducibility of Results.
Abstract
This study was performed to assess: (1) the inter- and intrasubject variability of gastric emptying measurements by a scintigraphic method in 12 healthy subjects and 14 diabetic patients, and (2) the reproducibility of diagnosis of either the presence or absence of gastroparesis. To address this issue, radiolabeled solid-liquid meals were ingested by all subjects on two separate days. High intersubject variability of gastric emptying measurements was shown in both populations. Intrasubject variability was higher in diabetic patients than in healthy subjects. However, there was no significant difference between the means of any parameters obtained on two separate days. The reproducibility of the diagnosis of gastroparesis was excellent for all parameters; the solid half emptying time was the most reproducible parameter (92% in healthy subjects and 93% in diabetic patients). The means +/- SD of the difference between the two separate days' half emptying time results were -10.6 +/- 41.3 min for solids and -4.8 +/- 36.6 min for liquids and were not statistically different from zero. Only one difference between the half emptying time results on two separate days was not in the 95% confidence interval for both solids and liquids; however, this result came from a diabetic patient with obvious gastroparesis on both days. Thus: (1) in spite of high inter- and intrasubject variability, the scintigraphic method of measuring gastric emptying is highly reproducible for the diagnosis of gastroparesis; (2) reproducibility is better in healthy subjects than in diabetic patients; and (3) the knowledge of intrasubject variability allows assessment of the required sample sizes for pharmacological studies using prokinetic medications.
PubMed: 8281844
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A scintigraphic study in healthy subjects and diabetic patients.</title><author><name sortKey="Lartigue, S" uniqKey="Lartigue S">S Lartigue</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire Fonctions Digestives et Nutrition, CHU Nord, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Fonctions Digestives et Nutrition, CHU Nord, Nantes</wicri:regionArea><placeName><region type="région">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Bizais, Y" uniqKey="Bizais Y">Y Bizais</name></author><author><name sortKey="Des Varannes, S B" uniqKey="Des Varannes S">S B Des Varannes</name></author><author><name sortKey="Murat, A" uniqKey="Murat A">A Murat</name></author><author><name sortKey="Pouliquen, B" uniqKey="Pouliquen B">B Pouliquen</name></author><author><name sortKey="Galmiche, J P" uniqKey="Galmiche J">J P Galmiche</name></author></titleStmt><publicationStmt><date when="1994">1994</date><idno type="RBID">pubmed:8281844</idno><idno type="pmid">8281844</idno><idno type="wicri:Area/Main/Corpus">004D68</idno><idno type="wicri:Area/Main/Curation">004D68</idno><idno type="wicri:Area/Main/Exploration">004985</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Diabetes Mellitus, Type 1 (complications)</term><term>Diabetes Mellitus, Type 1 (physiopathology)</term><term>Diabetes Mellitus, Type 1 (radionuclide imaging)</term><term>Female</term><term>Food</term><term>Gastric Emptying (physiology)</term><term>Humans</term><term>Indium Radioisotopes (diagnostic use)</term><term>Male</term><term>Middle Aged</term><term>Pentetic Acid (diagnostic use)</term><term>Reproducibility of Results</term><term>Stomach (radionuclide imaging)</term><term>Stomach Diseases (etiology)</term><term>Stomach Diseases (radionuclide imaging)</term><term>Technetium (diagnostic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Indium Radioisotopes</term><term>Pentetic Acid</term><term>Technetium</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Diabetes Mellitus, Type 1</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Stomach Diseases</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gastric Emptying</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Diabetes Mellitus, Type 1</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Diabetes Mellitus, Type 1</term><term>Stomach</term><term>Stomach Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Food</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reproducibility of Results</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study was performed to assess: (1) the inter- and intrasubject variability of gastric emptying measurements by a scintigraphic method in 12 healthy subjects and 14 diabetic patients, and (2) the reproducibility of diagnosis of either the presence or absence of gastroparesis. To address this issue, radiolabeled solid-liquid meals were ingested by all subjects on two separate days. High intersubject variability of gastric emptying measurements was shown in both populations. Intrasubject variability was higher in diabetic patients than in healthy subjects. However, there was no significant difference between the means of any parameters obtained on two separate days. The reproducibility of the diagnosis of gastroparesis was excellent for all parameters; the solid half emptying time was the most reproducible parameter (92% in healthy subjects and 93% in diabetic patients). The means +/- SD of the difference between the two separate days' half emptying time results were -10.6 +/- 41.3 min for solids and -4.8 +/- 36.6 min for liquids and were not statistically different from zero. Only one difference between the half emptying time results on two separate days was not in the 95% confidence interval for both solids and liquids; however, this result came from a diabetic patient with obvious gastroparesis on both days. Thus: (1) in spite of high inter- and intrasubject variability, the scintigraphic method of measuring gastric emptying is highly reproducible for the diagnosis of gastroparesis; (2) reproducibility is better in healthy subjects than in diabetic patients; and (3) the knowledge of intrasubject variability allows assessment of the required sample sizes for pharmacological studies using prokinetic medications.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">8281844</PMID><DateCreated><Year>1994</Year><Month>02</Month><Day>17</Day></DateCreated><DateCompleted><Year>1994</Year><Month>02</Month><Day>17</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0163-2116</ISSN><JournalIssue CitedMedium="Print"><Volume>39</Volume><Issue>1</Issue><PubDate><Year>1994</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Digestive diseases and sciences</Title><ISOAbbreviation>Dig. Dis. Sci.</ISOAbbreviation></Journal><ArticleTitle>Inter- and intrasubject variability of solid and liquid gastric emptying parameters. A scintigraphic study in healthy subjects and diabetic patients.</ArticleTitle><Pagination><MedlinePgn>109-15</MedlinePgn></Pagination><Abstract><AbstractText>This study was performed to assess: (1) the inter- and intrasubject variability of gastric emptying measurements by a scintigraphic method in 12 healthy subjects and 14 diabetic patients, and (2) the reproducibility of diagnosis of either the presence or absence of gastroparesis. To address this issue, radiolabeled solid-liquid meals were ingested by all subjects on two separate days. High intersubject variability of gastric emptying measurements was shown in both populations. Intrasubject variability was higher in diabetic patients than in healthy subjects. However, there was no significant difference between the means of any parameters obtained on two separate days. The reproducibility of the diagnosis of gastroparesis was excellent for all parameters; the solid half emptying time was the most reproducible parameter (92% in healthy subjects and 93% in diabetic patients). The means +/- SD of the difference between the two separate days' half emptying time results were -10.6 +/- 41.3 min for solids and -4.8 +/- 36.6 min for liquids and were not statistically different from zero. Only one difference between the half emptying time results on two separate days was not in the 95% confidence interval for both solids and liquids; however, this result came from a diabetic patient with obvious gastroparesis on both days. Thus: (1) in spite of high inter- and intrasubject variability, the scintigraphic method of measuring gastric emptying is highly reproducible for the diagnosis of gastroparesis; (2) reproducibility is better in healthy subjects than in diabetic patients; and (3) the knowledge of intrasubject variability allows assessment of the required sample sizes for pharmacological studies using prokinetic medications.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lartigue</LastName><ForeName>S</ForeName><Initials>S</Initials><Affiliation>Laboratoire Fonctions Digestives et Nutrition, CHU Nord, Nantes, France.</Affiliation></Author><Author ValidYN="Y"><LastName>Bizais</LastName><ForeName>Y</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Des Varannes</LastName><ForeName>S B</ForeName><Initials>SB</Initials></Author><Author ValidYN="Y"><LastName>Murat</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Pouliquen</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Galmiche</LastName><ForeName>J P</ForeName><Initials>JP</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Dig Dis Sci</MedlineTA><NlmUniqueID>7902782</NlmUniqueID><ISSNLinking>0163-2116</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>7440-26-8</RegistryNumber><NameOfSubstance>Technetium</NameOfSubstance></Chemical><Chemical><RegistryNumber>7A314HQM0I</RegistryNumber><NameOfSubstance>Pentetic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Diabetes Mellitus, Type 1</DescriptorName><QualifierName MajorTopicYN="N">complications</QualifierName><QualifierName MajorTopicYN="N">physiopathology</QualifierName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Food</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Gastric Emptying</DescriptorName><QualifierName MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Pentetic Acid</DescriptorName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Stomach</DescriptorName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Stomach Diseases</DescriptorName><QualifierName MajorTopicYN="N">etiology</QualifierName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Technetium</DescriptorName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1994</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1994</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1994</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8281844</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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